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Selected publications

*Levi DI, *Wyrosdic JC, Hicks AI, Andrade MA, Toney GM, Prager-Khoutorsky M, Bourque CW (2021) High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons. Cell Reports 34, 108866. doi: 10.1016. [PDF]  *co-first authors

Gizowski C and Bourque CW (2020) Sodium regulates clock time and output via an excitatory GABAergic pathway. Nature 583, 421-424.

Ciura S, Prager-Khoutorsky M, Thirouin ZS, Wyrosdic JC, Olson JE, Liedtke W, Bourque CW (2018) Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission. Cell Reports 23, 2245-2253. [PDF]

Gizowski C and Bourque CW (2018) The neural basis of homeostatic and anticipatory thirst. Nature Reviews Nephrology 14, 11-25

Gizowski C and Bourque CW (2017) Neurons that drive and quench thirst. Science 357, 1092-1093.

Gizowski C, Zaelzer C and Bourque CW (2016) Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep. Nature 537, 685-688.

Zaelzer C, Hua P, Prager-Khoutorsky M, Ciura S, Voisin DL, Liedtke W and Bourque CW. (2015) ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. Cell Reports
13, 23-30. [PDF]

Choe KY, Han SY, Gaub P, Shell B, Voisin DL, Knapp BA, Barker PA, Brown CH, Cunningham JT and Bourque CW. (2015) High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons. Neuron 85, 549-560. [PDF]

Prager-Khoutorsky M, Khoutorsky A and Bourque CW (2014) Unique Interweaved Microtubule Scaffold Mediates Osmosensory Transduction via Physical Interaction with TRPV1. Neuron 83, 866-878. [PDF]

Stachniak TJ, Trudel E and Bourque CW (2014) Cell-Specific Retrograde Signals Mediate Antiparallel Effects of Angiotensin II on Osmoreceptor Afferents to Vasopressin and Oxytocin Neurons. Cell Reports 8, 355-362. [PDF]

Prager-Khoutorsky and Bourque CW (2015) - Mechanical basis of osmosensory transduction in magnocellular neurosecretory neurones of the rat supraoptic nucleus – Journal of Neuroendocrinology 27, 507-515 [Green Open access file]

Sudbury JR and Bourque CW (2013) Dynamic and permissive roles of TRPV1 and TRPV4 channels for thermosensation in mouse supraoptic magnocellular neurosecretory neurons. J Neuroscience 33, 17160-5. [PDF]

Choe KY, Olson JE and Bourque CW (2012) Taurine release by astrocytes modulates osmosensitive glycine receptor tone and excitability in the adult supraoptic nucleus. J Neuroscience 32, 12518-27.  [PDF]

Trudel E and Bourque CW (2012) Circadian modulation of osmoregulated firing in rat supraoptic nucleus neurones – Journal of Neuroendocrinology 24, 577-586.  [Green Open Access file]

Ciura S, Liedtke W and Bourque CW (2011) Hypertonicity-sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving trpv1 but not trpv4. J Neuroscience 31, 14669-76.  [PDF]

Trudel E and Bourque CW (2010) Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep. Nature Neuroscience 13, 467-474.  [Green Open Access file]

Sudbury JR, Sharif-Naeini R and Bourque CW (2010) Osmotic and thermal control of magnocellular neurosecretory neurons--role of an N-terminal variant of trpv1. European Journal of Neuroscience 32, 2022-2030.  [Green Open Access file]

Prager-Khoutorsky M and Bourque CW (2010) Osmosensation in vasopressin neurons: changing actin density to optimize function. Trends in Neurosciences 33, 76-83. [Green Open Acces file]

Bourque CW (2008) Central mechanisms of osmosensation and systemic osmoregulation. Nature Reviews Neuroscience 9, 519-531.

Sharif-Naeini R, Ciura S and Bourque CW (2008) Trpv1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia. Neuron 58, 179-181.  [PDF]















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